OncoMatch/Clinical Trials/NCT04741945
Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS
Is NCT04741945 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Metformin for preleukemia.
Treatment: Metformin — This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).
Check if I qualifyExtracted eligibility criteria
Disease stage
Required: Stage VERY LOW-RISK, LOW-RISK (IPSS-R)
very low- or low-risk disease (IPSS-R score ≤3) in addition to a bone marrow blast percentage <5
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: metformin
Any prior treatment with metformin
Cannot have received: immunosuppressive therapy
Exception: corticosteroids
immunosuppressive therapy (with the exception of corticosteroids) within the past year
Cannot have received: chemotherapy
chemotherapy within the past year
Cannot have received: granulocyte colony-stimulating factor
Treatment with granulocyte colony-stimulating factor within the past 30 days
Cannot have received: hypomethylating agents (azacitidine, decitabine)
Prior therapy with hypomethylating agents (i.e., azacitidine, decitabine)
Lab requirements
Blood counts
Peripheral blood cytopenia is defined as hemoglobin (hgb) <11.3 g/dL (7 mmol/L) in women and hgb <12.9 g/dL (8 mmol/L) in men, platelet count <150 x 10^9/L, or neutrophil count <1.8 x 10^9/L
Kidney function
eGFR <45 mL/min
Liver function
total serum bilirubin >1.5 × upper limit of the normal range (ULN), serum alanine transaminase >3 × ULN
Cardiac function
severe cardiac disease (NYHA class 3-4)
eGFR <45 mL/min; total serum bilirubin >1.5 × ULN, serum alanine transaminase >3 × ULN; severe cardiac disease (NYHA class 3-4); Peripheral blood cytopenia is defined as hemoglobin (hgb) <11.3 g/dL (7 mmol/L) in women and hgb <12.9 g/dL (8 mmol/L) in men, platelet count <150 x 10^9/L, or neutrophil count <1.8 x 10^9/L
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify