OncoMatch/Clinical Trials/NCT04703101
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
Is NCT04703101 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Capecitabine and Fluorouracil for locally advanced rectal carcinoma.
Treatment: Capecitabine · Fluorouracil · Leucovorin · Oxaliplatin — This phase I trial investigates how well short-course radiation therapy followed by combination chemotherapy works in treating patients with stage II-III rectal cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as leucovorin, fluorouracil, oxaliplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving short-course radiation therapy and combination chemotherapy may reduce the need for surgery and therefore improve quality of life.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Disease stage
Required: Stage II, III
Performance status
KARNOFSKY OR ECOG 0–2
Karnofsky performance status (KPS) >= 70 or Eastern Cooperative Oncology Group (ECOG) 0-2
Prior therapy
Cannot have received: radiation therapy
Lab requirements
Blood counts
ANC > 1.5 cell/mm^3; Hgb > 8.0 gm/dL; PLT > 150,000/mm^3
Liver function
Total bilirubin <= 1.5 x upper limit of normal; AST and ALT <= 3 x upper limit of normal
ANC > 1.5 cell/mm^3; Hgb > 8.0 gm/dL; PLT > 150,000/mm^3; Total bilirubin <= 1.5 x upper limit of normal; AST and ALT <= 3 x upper limit of normal
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, California
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