OncoMatch/Clinical Trials/NCT04678648
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
Is NCT04678648 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including RSC-1255 Dose Escalation and RSC-1255 Dose Expansion for advanced malignant solid neoplasm.
Treatment: RSC-1255 Dose Escalation · RSC-1255 Dose Expansion — RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing therapies known to provide clinical benefit, have disease that has progressed after standard therapy, or have previously failed other therapies. The study has two phases. The purpose of Phase 1a (Dose Escalation) is to confirm the appropriate treatment dose and Phase 1b (Dose Expansion) is to characterize the safety and efficacy of RSC-1255.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Non-Small Cell Lung Carcinoma
Colorectal Cancer
Glioblastoma
Pancreatic Cancer
Biomarker criteria
Required: KRAS any mutation
documented RAS mutations
Required: NRAS any mutation
documented RAS mutations
Required: HRAS any mutation
documented RAS mutations
Disease stage
Required: Stage IV
advanced or metastatic malignancy
Prior therapy
Must have received: any therapy known to provide clinical benefit
Participant is intolerant of existing therapy(ies) known to provide clinical benefit for their condition; Malignancy is refractory to existing therapy(ies) known to potentially provide clinical benefit; Malignancy has progressed on standard therapy
Cannot have received: cancer therapy
Participants receiving cancer therapy at the time of enrollment
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of California, Los Angeles (UCLA) Department of Medicine - Hematology/Oncology · Los Angeles, California
- Sarah Cannon, SCRI Oncology Partners - Health One · Denver, Colorado
- Sarah Cannon, SCRI Oncology Partners · Nashville, Tennessee
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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