OncoMatch/Clinical Trials/NCT04665947
First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer
Is NCT04665947 recruiting? Yes, currently enrolling (Jun 2026). This Early Phase 1 trial studies [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G. for metastatic pancreatic cancer.
Treatment: [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G. — This is a Phase I, first-in-human study to evaluate the safety and efficacy of the \[68Ga\]Ga DOTA-5G and \[177Lu\]Lu DOTA-ABM-5G theranostic pair in patients with locally advanced or metastatic pancreatic adenocarcinoma (PDAC).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Pancreatic Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: systemic chemotherapy
Participant must have documented tumor progression during or following at least one prior systemic regimen
Cannot have received: radiation therapy for advanced or metastatic disease
Previous radiation therapy for the treatment of advanced or metastatic disease
Lab requirements
Blood counts
Absolute neutrophil count (ANC) ≥ 1000 cells/mm3; Platelet count ≥ 100,000/mm3; Hemoglobin ≥ 8 g/dL; INR>1.2; PTT>5 seconds above UNL [excluded]
Kidney function
Creatinine ≤ 2 times ULN
Liver function
AST, ALT, alkaline phosphatase ≤ 5 times upper limit of normal (ULN); Total bilirubin ≤ 2 times ULN
Hematologic parameters defined as: ANC ≥ 1000 cells/mm3; Platelet count ≥ 100,000/mm3; Hemoglobin ≥ 8 g/dL. Blood chemistry levels defined as: AST, ALT, alkaline phosphatase ≤ 5 times ULN; Total bilirubin ≤ 2 times ULN; Creatinine ≤ 2 times ULN. INR>1.2; PTT>5 seconds above UNL [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of California Davis · Sacramento, California
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT04665947 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior radiation therapy for advanced or metastatic disease disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages