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OncoMatch/Clinical Trials/NCT04614103

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

Is NCT04614103 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including LN-145 and LN-145 for metastatic non small cell lung cancer.

Phase 2RecruitingIovance Biotherapeutics, Inc.NCT04614103Data as of May 2026

Treatment: LN-145 · LN-145 — This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer

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Extracted eligibility criteria

Cancer type

Small Cell Lung Cancer

Biomarker criteria

Required: ALK wild-type

Required: EGFR wild-type

Required: ROS1 wild-type

Disease stage

Required: Stage IV

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Max 2 prior lines
Min 1 prior line

Must have received: immune checkpoint inhibitor — first-line

documented radiographic disease progression on or after the first-line therapy, including concurrent or sequential ICI and platinum-based chemotherapy ± bevacizumab

Must have received: platinum-based chemotherapy — first-line

documented radiographic disease progression on or after the first-line therapy, including concurrent or sequential ICI and platinum-based chemotherapy ± bevacizumab

Cannot have received: cell therapy

prior cell therapy within the past 20 years

Cannot have received: allogeneic organ transplant

allogeneic organ transplant

Lab requirements

Cardiac function

lvef > 45%, nyha class 1

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • City of Hope · Duarte, California
  • UC San Diego Moores Cancer Center · La Jolla, California
  • University of Southern California · Los Angeles, California
  • Christiana Care Health System · Newark, Delaware
  • University of Florida Health Cancer Center · Gainesville, Florida

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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