OncoMatch/Clinical Trials/NCT04593589

Submandibular Gland Stem Cell Transplantation

Is NCT04593589 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies non-drug interventions for head and neck cancer.

Phase 1RecruitingUniversity Medical Center GroningenNCT04593589Data as of May 2026

This study is a phase I safety and feasibility study to treat head and neck cancer patients with autologous salivary gland stem cell transplantation after postoperative (chemo)radiotherapy.

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Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Performance status

WHO 0–2

Prior therapy

Must have received: surgery — primary resection of tumour including an electively or therapeutic ipsilateral neck dissection (at least levels Ib to III, including the submandibular gland)

Primary resection of tumour including an electively or therapeutic ipsilateral neck dissection (at least levels Ib to III, including the submandibular gland)

Must have received: radiation therapy — postoperative radiotherapy or chemoradiation, including prophylactic or therapeutic irradiation of the contralateral side of the neck (where the remaining submandibular gland is), including at least levels Ib to IV), next to irradiation of the tumour bed and ipsilateral neck (current standard)

Postoperative radiotherapy or chemoradiation, including prophylactic or therapeutic irradiation of the contralateral side of the neck (where the remaining submandibular gland is), including at least levels Ib to IV), next to irradiation of the tumour bed and ipsilateral neck (current standard)

Cannot have received: primary (definitive) radiotherapy

Primary (definitive) radiotherapy, with or without systemic treatment

Cannot have received: previous radiotherapy of the head and neck region (re-irradiation)

Previous radiotherapy of the head and neck region (re-irradiation)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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