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OncoMatch/Clinical Trials/NCT04547049

A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies

Is NCT04547049 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments for leukemia.

Phase 3RecruitingFirst Affiliated Hospital of Zhejiang UniversityNCT04547049Data as of May 2026

Treatment: Cytarabine · Busulfan · Cyclophosphamide · Me-CCNU · Rabbit antithymocyte globulin · Cyclosporin A · Mycophenolate Mofetil · MTXAn open, multi-center, randomized trial comparing haploidentical HSCTs from young non-first-degree and older first-degree donors in hematological malignancies

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Extracted eligibility criteria

Cancer type

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Must have received: allogeneic hematopoietic cell transplant — first

A first allo-HCT

Cannot have received: allogeneic hematopoietic cell transplant

Not the first allo-HCT

Lab requirements

Kidney function

No severe kidney insufficiency

Liver function

No severe liver insufficiency

Cardiac function

No severe heart insufficiency

Patients with severe heart, lung, liver and kidney insufficiency [excluded]; Adequate end-organ function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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