OncoMatch/Clinical Trials/NCT04536805
Relapse in Previously Irradiated Prostate Bed : Stereotactic Ablative Reirradiation Potentiated by Metformin
Is NCT04536805 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies Metformin for prostate cancer.
Treatment: Metformin — This phase I/II escalation dose study is assessing the efficacy of the recommended dose of stereotactic re-irradiation (SBRT) of relapses within the prostatectomy bed, potentiated by metformin
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Prostate Cancer
Performance status
WHO 0–1
Demographics
Prior therapy
Must have received: external radiotherapy — prostate lodge
Biochemical recurrence occurring at least 2 years after external radiotherapy to the prostate lodge and the end of hormone therapy
Must have received: hormone therapy
Biochemical recurrence occurring at least 2 years after external radiotherapy to the prostate lodge and the end of hormone therapy
Must have received: radical prostatectomy
for prostatic adenocarcinoma previously treated by radical prostatectomy
Cannot have received: metformin
Treatment with metformin in the last 3 months prior to inclusion
Cannot have received: investigational drug
Treatment with any investigational drug or participation in a clinical trial within 30 days prior to inclusion
Lab requirements
Kidney function
Creatinine clearance >= 45 mL/min
Creatinine clearance < 45 mL/min [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04536805 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior metformin, investigational drug disqualifies patients from enrollment.
Is this trial open to female patients?
No. This trial enrolls male patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages