OncoMatch/Clinical Trials/NCT04486755
Hypofractionated Accelerated Pelvic Nodal Radiotherapy (GCC 2048)
Is NCT04486755 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies non-drug interventions for prostate cancer.
A phase I trial to determine the safety of delivering three sequentially shorter RT schedules (20, 16, and 12 fractions) of HypoFx pelvic nodal RT in combination with a HypoFx, simultaneous integrated boost (SIB) to the prostate that have been designed to incrementally increased the biological equivalent dose (BED) to prostate cancer, while maintaining a constant BED to normal tissue toxicity.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Disease stage
Required: Stage INTERMEDIATE TO HIGH RISK
Patient's with intermediate to high risk prostate cancer and must be recommended to undergo pelvic as well as prostatic irradiation.
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: radical surgery (prostatectomy)
Previous radical surgery (prostatectomy), cryosurgery, or HIFU (High-intensity focused ultrasound) for prostate cancer
Cannot have received: cryosurgery
Previous radical surgery (prostatectomy), cryosurgery, or HIFU (High-intensity focused ultrasound) for prostate cancer
Cannot have received: high-intensity focused ultrasound (HIFU)
Previous radical surgery (prostatectomy), cryosurgery, or HIFU (High-intensity focused ultrasound) for prostate cancer
Cannot have received: pelvic irradiation
Previous pelvic irradiation or prostate brachytherapy
Cannot have received: prostate brachytherapy
Previous pelvic irradiation or prostate brachytherapy
Cannot have received: prostate brachytherapy
Planned prostate brachytherapy boost
Cannot have received: cytotoxic chemotherapy
Previous or concurrent cytotoxic chemotherapy for prostate cancer
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Maryland Proton Treatment Center · Baltimore, Maryland
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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