OncoMatch/Clinical Trials/NCT04473781
Interstitial Brachytherapy for the Treatment of Unresectable/Unablatable Kidney Cancer
Is NCT04473781 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies non-drug interventions for stage i renal cell cancer.
This phase I/II trial investigates the side effects of interstitial brachytherapy and to see how well it works in limiting the growth of large kidney cancer masses in patients with kidney cancer that have refused or are unable to undergo surgery or ablation (unresectable/unablatable). Brachytherapy, also known as internal radiation therapy, temporarily introduces a radiation source into or near the tumor to eradicate the tumor cells. Giving brachytherapy may potentially reduce the size of the kidney cancer mass that would otherwise not be amenable to surgical management and translate into lower risk of spread.
Check if I qualifyExtracted eligibility criteria
Cancer type
Renal Cell Carcinoma
Disease stage
Required: Stage I, II
Excluded: Stage LOCALLY ADVANCED (NODAL OR TUMOR THROMBUS), DISTANT (METASTATIC) DISEASE
No definitive evidence of locally advanced (nodal or tumor thrombus) or distant (metastatic) disease
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: systemic treatment
No prior systemic treatment for kidney cancer
Cannot have received: surgery
Prior surgery ... to the operative site
Cannot have received: radiation therapy
Prior ... radiation therapy to the operative site
Lab requirements
Blood counts
Hemoglobin > 9; ANC ≥ 1500/uL; Platelets ≥ 100,000/uL
Kidney function
eGFR ≥ 30
Liver function
AST and ALT ≤ 3.0 ULN; total bilirubin ≤ ULN
Hemoglobin > 9; ANC ≥ 1500/uL; Platelets ≥ 100,000/uL; AST and ALT ≤ 3.0 ULN; total bilirubin ≤ ULN; eGFR ≥ 30
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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