OncoMatch/Clinical Trials/NCT04437329
Nedaplatin Versus Cisplatin in Treatment for Nasopharyngeal Carcinoma
Is NCT04437329 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies multiple treatments including Docetaxel, nedaplatin, fluorouracil and Docetaxel, cisplatin, fluorouracil for nasopharyngeal carcinoma.
Treatment: Docetaxel, nedaplatin, fluorouracil · Docetaxel, cisplatin, fluorouracil · Nedaplatin · Cisplatin — To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Head and Neck Squamous Cell Carcinoma
Disease stage
Required: Stage III, IVA
Excluded: Stage T3-4N0
Performance status
KARNOFSKY 70–100
KARNOFSKY scale (KPS) > 70
Demographics
Prior therapy
Cannot have received: radiotherapy
Exception: diagnostic surgery allowed
History of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes
Cannot have received: chemotherapy
Exception: diagnostic surgery allowed
History of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes
Cannot have received: surgery
Exception: diagnostic surgery allowed
History of previous radiotherapy, chemotherapy, or surgery (except diagnostic) to the primary tumor or nodes
Lab requirements
Blood counts
WBC ≥ 4×10^9/l, platelet ≥ 100×10^9/l, hemoglobin ≥ 90g/l
Kidney function
creatinine ≤ 1.5×uln or ccr ≥ 60ml/min
Liver function
TBIL, ALT, AST ≤ 2.5×uln
WBC≥4×10^9/ l, platelet ≥ 100×10^9/ l and hemoglobin ≥ 90g/l; normal liver function test (TBIL、ALT、AST ≤ 2.5×uln); normal renal function test (creatinine ≤ 1.5×uln or ccr ≥ 60ml/min)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04437329 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage III or IVA is required.
Is there an age limit?
Yes. Patients must be 65 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages