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OncoMatch/Clinical Trials/NCT04343157

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Is NCT04343157 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for brain metastases, adult.

Phase 2RecruitingJona Hattangadi-GluthNCT04343157Data as of May 2026

In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in brain metastases patients.

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Extracted eligibility criteria

Disease stage

Metastatic disease required

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Cannot have received: whole brain radiation therapy

Previous whole brain radiation therapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Moores Cancer Center · San Diego, California

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