OncoMatch

OncoMatch/Clinical Trials/NCT04333537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Is NCT04333537 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies Imaging Agent for buccal mucosa squamous cell carcinoma.

Phase 2/3RecruitingNRG OncologyNCT04333537Data as of May 2026

Treatment: Imaging Agent — This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.

Check if I qualify

Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Performance status

ZUBROD 0–2

Prior therapy

Cannot have received: systemic chemotherapy

Exception: prior chemotherapy for different cancer(s) is allowable

Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for different cancer(s) is allowable

Cannot have received: radiation therapy

Exception: if would result in overlap of radiation therapy fields

Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields

Cannot have received: surgery involving the lateral neck, including neck dissection or gross injury to the neck

Exception: prior thyroid and central neck surgery is permissible; biopsy is permitted

Prior surgery involving the lateral neck, including neck dissection or gross injury to the neck that would preclude surgical dissection for this trial. Prior thyroid and central neck surgery is permissible; biopsy is permitted.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • University of Alabama at Birmingham Cancer Center · Birmingham, Alabama
  • Banner MD Anderson Cancer Center · Gilbert, Arizona
  • Mayo Clinic Hospital in Arizona · Phoenix, Arizona
  • Banner University Medical Center - Tucson · Tucson, Arizona
  • University of Arizona Cancer Center-North Campus · Tucson, Arizona

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify