OncoMatch/Clinical Trials/NCT04290663
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
Is NCT04290663 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies Systematic RAI-treatment for thyroid cancer.
Treatment: Systematic RAI-treatment — This trial is comparing two strategies in intermediate-risk differentiated thyroid cancer patients: Systematic radioiodine administration versus decision of radioiodine treatment guided by a post-operative work-up based on serum Tg values and diagnostic RAI scintigraphy
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Tumor Agnostic
Disease stage
Excluded: Stage PT1A, PT3, PT4, PT1AN0/X, PT1BN0/X, PT2N0/NX, PT1AN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT1BN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT2N1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT1AN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT1BN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT2N1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT2N0/NX WITHOUT EXTRA-THYROID EXTENSION, PT3B
T1b or T2 with minimal extra-thyroid extension into the perithyroidal soft tissues and/or pN1 with largest nodal dimension between 2 and 10 mm, without extra-capsular invasion and with a number of metastatic nodes ≤ 10 T1aN1 with largest nodal dimension between 2 and 10 mm, without extra-capsular invasion and with a number of metastatic nodes ≤ 10
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: total thyroidectomy
Patient treated by total thyroidectomy with macroscopically complete tumor resection (R0 or R1) ± neck dissection
Must have received: LT4 treatment
Post-operative LT4 treatment initiated at least 6 weeks before randomization
Cannot have received: lobectomy only
Patients who have undergone lobectomy only
Cannot have received: previous RAI treatment for thyroid cancer
Previous RAI treatment for thyroid cancer
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04290663 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior lobectomy only, previous RAI treatment for thyroid cancer disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify