OncoMatch/Clinical Trials/NCT04290663
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
Is NCT04290663 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Systematic RAI-treatment for thyroid cancer.
Treatment: Systematic RAI-treatment — This trial is comparing two strategies in intermediate-risk differentiated thyroid cancer patients: Systematic radioiodine administration versus decision of radioiodine treatment guided by a post-operative work-up based on serum Tg values and diagnostic RAI scintigraphy
Check if I qualifyExtracted eligibility criteria
Cancer type
Thyroid Cancer
Disease stage
Excluded: Stage PT1A, PT3, PT4, PT1AN0/X, PT1BN0/X, PT2N0/NX, PT1AN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT1BN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT2N1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION <2MM, PT1AN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT1BN1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT2N1 WITHOUT EXTRA-THYROID EXTENSION AND WITH NODAL LARGEST DIMENSION >10MM, PT2N0/NX WITHOUT EXTRA-THYROID EXTENSION, PT3B
T1b or T2 with minimal extra-thyroid extension into the perithyroidal soft tissues and/or pN1 with largest nodal dimension between 2 and 10 mm, without extra-capsular invasion and with a number of metastatic nodes ≤ 10 T1aN1 with largest nodal dimension between 2 and 10 mm, without extra-capsular invasion and with a number of metastatic nodes ≤ 10
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: total thyroidectomy
Patient treated by total thyroidectomy with macroscopically complete tumor resection (R0 or R1) ± neck dissection
Must have received: LT4 treatment
Post-operative LT4 treatment initiated at least 6 weeks before randomization
Cannot have received: lobectomy only
Patients who have undergone lobectomy only
Cannot have received: previous RAI treatment for thyroid cancer
Previous RAI treatment for thyroid cancer
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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