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OncoMatch/Clinical Trials/NCT04261244

NeoRad Breast Cancer Study

Is NCT04261244 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for breast cancer.

Phase 3RecruitingBielefeld UniversityNCT04261244Data as of May 2026

The NEORAD trial tests whether preoperative radiotherapy results in an improved DFS and less radiation induced late effect compared to postoperative radiotherapy in higher risk breast cancer after NACT.

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Extracted eligibility criteria

Cancer type

Breast Carcinoma

Disease stage

Grade: g1g2g3

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Cannot have received: endocrine therapy

Exception: sole neoadjuvant treatment

Neoadjuvant treatment solely with endocrine therapy

Cannot have received: radiation therapy

Exception: prior radiotherapy of the thorax

Prior radiotherapy of the thorax

Lab requirements

Cardiac function

No symptomatic coronary heart disease, prior heart attack, heart failure NYHA ≥II or AHA ≥C, pacemaker, and/or implanted defibrillator

Cardiac comorbidities: symptomatic coronary heart disease, prior heart attack, heart failure NYHA ≥II or AHA ≥C, pacemaker, and/or implanted defibrillator [excluded]

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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