OncoMatch/Clinical Trials/NCT04183712
Target Therapy With GEMOX in Recectable Gallbladder Carcinoma Patients Monitored by ctDNA
Is NCT04183712 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including gemcitabine and oxaliplatin. and Afatinib for gallbladder carcinoma.
Treatment: gemcitabine and oxaliplatin. · Afatinib — The purpose of this study is to evaluate the feasibility, efficacy and safety of target therapy according to genomic and proteomic profiling combined with GEMOX in recectable gallbladder carcinoma patients monitored by ctDNA.
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: HER2 (ERBB2) mutation
harboring mutations or abnormal activation of erb-b2 receptor tyrosine kinase signal pathway components
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: molecular target therapy
Anti-tumor molecular target therapy
Cannot have received: chemotherapy
Exception: chemotherapy in 6 months
anti-tumor chemotherapy in 6 months
Cannot have received: radiation therapy
lesions have been treated by irradiation
Cannot have received: other clinical trial therapy
participate in other therapeutic or interventional clinical trials
Lab requirements
Blood counts
white blood cells≥3×10^9/L, neutrophils≥1.5×10^9/L, platelets≥75×10^9/L , hemoglobin ≥ 90g/L
Kidney function
creatinine clearance rate≥60ml/min
Liver function
ALT≤5×upper limit of normal (ULN), AST≤5×ULN, the Child-Pugh classification for class A or B
Adequate hepatic, hematologic and renal functions(ALT≤5×upper limit of normal (ULN), AST≤5×ULN, the Child-Pugh classification for class A or B, white blood cells≥3×10^9/L, neutrophils≥1.5×10^9/L, platelets≥75×10^9/L , hemoglobin ≥ 90g/L, creatinine clearance rate≥60ml/min;
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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