OncoMatch/Clinical Trials/NCT04169763
Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery
Is NCT04169763 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Cisplatin and Nelfinavir for stage ii vulvar cancer ajcc v8.
Treatment: Cisplatin · Nelfinavir — This phase I trial studies the side effects and best dose of nelfinavir when given together with cisplatin and external beam radiation therapy in treating patients with vulvar cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery. Nelfinavir is an antiviral drug normally used to treat human immunodeficiency virus (HIV). Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy beams to kill tumor cells and shrink tumors. Giving nelfinavir, cisplatin, and external beam radiation therapy may work better than giving only cisplatin and external beam radiation therapy in treating patients with vulvar cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Disease stage
Excluded: Stage T1N0
Performance status
ECOG/GOG 0–2
Prior therapy
Cannot have received: pelvic or abdominal radiation
Patients who have received previous pelvic or abdominal radiation
Cannot have received: cytotoxic chemotherapy
Patients who have received previous...cytotoxic chemotherapy
Cannot have received: any previous therapy for this malignancy
Patients who have received previous...therapy of any kind for this malignancy
Lab requirements
Blood counts
anc >= 1,500/microliter; platelet count >= 100,000/microliter
Kidney function
creatinine < 2.0 mg/dl; egfr >= 30
Liver function
total bilirubin =< 1.5 times normal; sgot =< 3 times normal
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- M D Anderson Cancer Center · Houston, Texas
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