OncoMatch/Clinical Trials/NCT04166006
A Phase II Study on Adjuvant Vaccination with Dendritic Cells Loaded with Autologous Tumor Homogenate in Resected Stage IV Rare Cancers.
Is NCT04166006 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Autologous DC vaccine and Interleukin-2 for head neck tumors.
Treatment: Autologous DC vaccine · Interleukin-2 — Single-arm, monocentric trial to assess safety and immunological efficacy of adjuvant vaccination with autologous dendritic cells loaded with autologous tumour homogenate after curative resection for stage IV rare cancers (In Head/Neck tumors (H\&N), NEuroendocrine Tumors (NET) and Soft Tissue Sarcomas (STS).
Check if I qualifyExtracted eligibility criteria
Cancer type
Neuroendocrine Tumor
Sarcoma
Disease stage
Required: Stage IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: surgery — radical intent
surgically treated with radical intent
Lab requirements
Blood counts
Haemoglobin >10 g/dl; WBC ≥3000/μl; ANC ≥1500/μl; platelets ≥75000/μl
Kidney function
serum creatinine <1.5x upper institutional reference level
Liver function
AST and ALT <3x upper institutional reference level; total bilirubin <1.5x upper institutional reference level
Cardiac function
Patients aged 70 years or older must have left ventricular ejection fraction not lower than 55% as assessed by echocardiography
Haemoglobin >10 g/dl; White blood cells ≥3000/μl; Absolute neutrophil count ≥1500/μl; Platelets≥75000/μl; AST and ALT <3x upper institutional reference level; Total bilirubin <1.5x upper institutional reference level; Serum creatinine <1.5x upper institutional reference level. Patients aged 70 years or older must have left ventricular ejection fraction not lower than 55% as assessed by echocardiography.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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