OncoMatch/Clinical Trials/NCT04106115
DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr
Is NCT04106115 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1/2 trial studies multiple treatments including S-488210/S-488211 and Durvalumab for bladder cancer.
Treatment: Durvalumab · S-488210/S-488211 — DURANCE is a two part, phase Ib/II, multi-centre study to assess the safety and activity of S-488210/S-488211 in combination with durvalumab, in patients with non-muscle invasive bladder cancer (NMIBC).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Other
Cancer type
Urothelial Carcinoma
Performance status
WHO 0–1
Prior therapy
Cannot have received: anti-pd-1/pd-l1/ctla-4 monoclonal antibody or other novel immune-oncology agent
Cannot have received: allogeneic stem cell or solid organ transplantation
Lab requirements
Blood counts
haemoglobin ≥9.0 g/dl; absolute neutrophil count ≥1.5 x 10^9/l (≥150,000 per mm3); platelet count ≥100 x 10^9/l (≥100,000 per mm3); inr ≤1.5 and aptt ≤1.5 x uln (applies only to patients not receiving therapeutic anticoagulation; patients receiving therapeutic anticoagulation should be on a stable dose)
Kidney function
measured creatinine clearance ≥40 ml/min or calculated creatinine clearance ≥40 ml/min using cockcroft-gault formula
Liver function
total bilirubin ≤1.5 x uln (<3.0 x uln for patients with gilbert's syndrome); ast or alt ≤2.5 x uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04106115 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior anti-pd-1/pd-l1/ctla-4 monoclonal antibody or other novel immune-oncology agent, allogeneic stem cell or solid organ transplantation disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages