OncoMatch/Clinical Trials/NCT04089631
Circulating Tumour DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation
Is NCT04089631 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Capecitabine for colon cancer stage ii.
Treatment: Capecitabine — The CIRCULATE study evaluates the adjuvant therapy in patients with colon cancer UICC stage II. The primary aim of the study is to compare the disease free survival in patients who are positive for postoperative circulating tumour DNA with vs. without capecitabine.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Biomarker criteria
Excluded: MSH2 deficiency
mismatch repair deficiency (dMMR)
Excluded: MSH6 deficiency
mismatch repair deficiency (dMMR)
Excluded: MLH1 deficiency
mismatch repair deficiency (dMMR)
Excluded: PMS2 deficiency
mismatch repair deficiency (dMMR)
Excluded: DPYD deficiency
Known dihydropyrimidine dehydrogenase (DPD)-deficiency
Disease stage
Required: Stage II
Excluded: Stage III, IV
Performance status
WHO 0–1
Prior therapy
Must have received: surgery — resection
Resected colon cancer stage II, OR resected rectal cancer stage II
Cannot have received: neoadjuvant therapy
Neoadjuvant therapy before resection
Lab requirements
Blood counts
Leukocytes < 3,0 Gpt/l; Neutrophil granulocytes < 1,5 Gpt/l; Thrombocytes < 100 Gpt/l [excluded]
Kidney function
Creatinine clearance (calculated according Cockcroft-Gault) < 30 ml/min [excluded]
Liver function
alanine aminotransferase (ALAT) or (aspartate aminotransferase) ASAT > 3x ULN [excluded]
Contra indications for chemotherapy, especially: Leukocytes < 3,0 Gpt/l; Neutrophil granulocytes < 1,5 Gpt/l; Thrombocytes < 100 Gpt/l; alanine aminotransferase (ALAT) or (aspartate aminotransferase) ASAT > 3x ULN; Creatinine clearance (calculated according Cockcroft-Gault) < 30 ml/min
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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