OncoMatch/Clinical Trials/NCT04014530
Pembrolizumab With Ataluren in Patients With Metastatic pMMR and dMMR Colorectal Carcinoma or Metastatic dMMR Endometrial Carcinoma: the ATAPEMBRO Study
Is NCT04014530 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies Ataluren + Pembrolizumab for colorectal cancer.
Treatment: Ataluren + Pembrolizumab — Single Center, open label, Phase I-II trial designed to test the safety and efficacy of the combination of Ataluren and Pembrolizumab for the treatment of metastatic mismatch repair deficient and proficient colorectal adenocarcinoma and metastatic mismatch repair deficient endometrial carcinoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: any cancer therapy regimen — metastatic CRC
Have received at least 1 prior cancer therapy regimen for metastatic CRC, or have refused palliative chemotherapy
Cannot have received: anti-PD-1 therapy
Has history of prior treatment with anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, anti-OX-40, anti-CD40, or anti-CTLA-4 antibodies
Cannot have received: anti-cancer monoclonal antibody
Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks earlier
Cannot have received: chemotherapy
Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to study day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a previously administered agent
Cannot have received: targeted small molecule therapy
Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to study day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a previously administered agent
Cannot have received: radiation therapy
Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to study day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a previously administered agent
Lab requirements
Blood counts
normal organ and marrow function as defined in protocol
Kidney function
normal organ and marrow function as defined in protocol
Liver function
normal organ and marrow function as defined in protocol
Have normal organ and marrow function as defined in protocol
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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