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OncoMatch/Clinical Trials/NCT04009265

Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma

Is NCT04009265 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies adjuvant treatment for esophageal squamous cell carcinoma.

Phase 3RecruitingFujian Medical University Union HospitalNCT04009265Data as of May 2026

Treatment: adjuvant treatmentA multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer.

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Extracted eligibility criteria

Cancer type

Esophageal Carcinoma

Disease stage

Required: Stage PN1-2, PT1B-3N1-2M0 (AJCC 8th edition)

According to the 8th edition of AJCC staging, pN1-2 (pT1b-3N1-2M0) stage of esophageal cancer

Performance status

WHO 0–1

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Must have received: surgery — curative (R0 resection)

Radical resection of tumors (R0) was performed

Cannot have received: antineoplastic treatment

No antineoplastic treatments before operation

Cannot have received: anti-tumor treatment

Received other anti-tumor treatment before enrollment

Lab requirements

Kidney function

Laboratory examination within one week before the adjuvant treatment confirmed that the renal function met the requirements

Liver function

Laboratory examination within one week before the adjuvant treatment confirmed that the hepatic function met the requirements

Cardiac function

Laboratory examination within one week before the adjuvant treatment confirmed that the cardiac function met the requirements

Laboratory examination within one week before the adjuvant treatment confirmed that the cardiac, hepatic and renal functions met the requirements

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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