OncoMatch/Clinical Trials/NCT03997643
Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial
Is NCT03997643 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for head and neck cancer.
The goal of this randomized treatment study is to formally compare quality of life in patients with at least one pN0 hemi-neck after resection of a squamous cell carcinoma of the oral cavity treated with a primary radiation therapy versus a secondary targeted radiation therapy approach, to provide a high level of evidence to guide the selection of treatment options.
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Disease stage
Required: Stage PT3, PT4
pT3 or pT4 disease
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: surgery — oral cavity and at least ipsilateral selective neck dissection
resected oral cavity squamous cell carcinoma with at least ipsilateral selective neck dissection
Cannot have received: radiation therapy
Prior head and neck radiation at any time
Cannot have received: surgery
Prior oncologic head and neck surgery in the oral cavity or neck
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Miami Cancer Institute · Miami, Florida
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