OncoMatch/Clinical Trials/NCT03915678
Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors
Is NCT03915678 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for solid tumor, adult.
Treatment: Association atezolizumab + BDB001 + RT · Association atezolizumab + BDB001+ RT · Association atezolizumab + BDB001+ RT · Association atezolizumab + BDB001 + RT · Association atezolizumab + BDB001 + RT · Association atezolizumab + BDB001 + RT — Basket trial concept to independently and simultaneously assess the effects of the association of atezolizumab + BDB001 + radiotherapy in multiple solid tumors.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Pancreatic Cancer
Small Cell Lung Cancer
Melanoma
Urothelial Carcinoma
Triple-Negative Breast Cancer
Breast Carcinoma
Biomarker criteria
Required: CDKN2A overexpression (IHC p16 positive)
in case of viral genotype is not available, IHC p16 positive must be provided
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: tlr agonist
Lab requirements
Blood counts
Adequate hematological function required
Kidney function
Adequate renal function required
Liver function
Adequate hepatic function required
Cardiac function
No congestive heart failure ≥ NYHA class 2, unstable angina, new-onset angina, myocardial infarction <6 months, uncontrolled arrhythmias, LVEF <50%, prior pericardial disorder
Adequate hematological, renal, metabolic and hepatic functions; cardiac criteria: congestive heart failure ≥ NYHA class 2, unstable angina, new-onset angina, myocardial infarction less than 6 months before inclusion, uncontrolled cardiac arrhythmias, known left ventricular ejection fraction (LVEF) <50%, previously experience of pericardial disorder
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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