OncoMatch/Clinical Trials/NCT03913117

Study of Treatment for HPV16+ ASC-US or LSIL

Is NCT03913117 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including pNGVL4aCRTE6E7L2 and TA-CIN for asc-us.

Phase 1RecruitingUniversity of Alabama at BirminghamNCT03913117Data as of May 2026

Treatment: pNGVL4aCRTE6E7L2 · TA-CIN — Phase I clinical trial to assess safety of pNGVL4aCRTE6E7L2 DNA and TA-CIN protein vaccinations, and to seek the appropriate dose of the pNGVL4aCRTE6E7L2 DNA vaccine

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Extracted eligibility criteria

Biomarker criteria

Required: HPV16 positive

Disease stage

Excluded: Stage CIN2+

Prior therapy

Cannot have received: HPV vaccine

Prior vaccination with any HPV antigen (prophylactic or therapeutic)

Cannot have received: LEEP or cervical conization procedure

Patients who have had a prior LEEP or cervical conization procedure

Lab requirements

Blood counts

White blood cell count > 3,000; Absolute lymphocyte number > 500; Absolute neutrophil count > 1,000; Platelets > 90,000; Hemoglobulin > 9

Kidney function

Creatinine < 2.5X the institutional limit of normal

Liver function

Total bilirubin <3 X the institutional limit of normal; AST(SGOT)/ALT(SGPT) <3 X the institutional limit of normal

Patients must have adequate organ function at the time of enrollment as defined by the following parameters: White blood cell count > 3,000; Absolute lymphocyte number > 500; Absolute neutrophil count > 1,000; Platelets > 90,000; Hemoglobulin > 9; Total bilirubin <3 X the institutional limit of normal; AST(SGOT)/ALT(SGPT) <3 X the institutional limit of normal; Creatinine < 2.5X the institutional limit of normal

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

UAB | The University of Alabama at Birmingham · Birmingham, Alabama
Johns Hopkins University · Baltimore, Maryland

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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