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OncoMatch/Clinical Trials/NCT03832127

Evaluation of PET 18F-Fludarabine for the Initial Assessment and End-treatment of Symptomatic Multiple Myeloma Patients

Is NCT03832127 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies 18F-Fludarabine for myeloma.

Phase 1RecruitingNantes University HospitalNCT03832127Data as of Jun 2026Location: France

Treatment: 18F-FludarabineThe objective of this exploratory study is to evaluate, for the first time, the sensitivity of 18F-Fludarabine to the initial diagnosis of MM compared to FDG-PET and MRI. The interest of this molecule will also be investigated as part of the end-of-treatment therapeutic evaluation.

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Extracted eligibility criteria

Treatments studied

Other

18F-Fludarabine

Cancer type

Multiple Myeloma

Performance status

KARNOFSKY/ECOG 0–1

Karnofsky ≥ 70 or ECOG 0-1

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

neutropenia < 1000 PN/mm3; thrombocytopenia < 70,000/mm3 [excluded]

Kidney function

creatinine clearance < 50 ml/min [excluded]

Liver function

bilirubin > 35μmol/L and SGOT, SGPT, alkaline phosphatase greater than 3 N [excluded]

Neutropenia <1000 PN / mm3; Thrombocytopenia <70,000 / mm3; Hepatic impairment: bilirubin> 35μmol / L and SGOT, SGPT, alkaline phosphatase greater than 3 N; Renal impairment defined by creatinine clearance <50 ml / min

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT03832127 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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