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OncoMatch/Clinical Trials/NCT03832127

Evaluation of PET 18F-Fludarabine for the Initial Assessment and End-treatment of Symptomatic Multiple Myeloma Patients

Is NCT03832127 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies 18F-Fludarabine for myeloma.

Phase 1RecruitingNantes University HospitalNCT03832127Data as of May 2026

Treatment: 18F-FludarabineThe objective of this exploratory study is to evaluate, for the first time, the sensitivity of 18F-Fludarabine to the initial diagnosis of MM compared to FDG-PET and MRI. The interest of this molecule will also be investigated as part of the end-of-treatment therapeutic evaluation.

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Performance status

KARNOFSKY/ECOG 0–1

Karnofsky ≥ 70 or ECOG 0-1

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

neutropenia < 1000 PN/mm3; thrombocytopenia < 70,000/mm3 [excluded]

Kidney function

creatinine clearance < 50 ml/min [excluded]

Liver function

bilirubin > 35μmol/L and SGOT, SGPT, alkaline phosphatase greater than 3 N [excluded]

Neutropenia <1000 PN / mm3; Thrombocytopenia <70,000 / mm3; Hepatic impairment: bilirubin> 35μmol / L and SGOT, SGPT, alkaline phosphatase greater than 3 N; Renal impairment defined by creatinine clearance <50 ml / min

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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