OncoMatch/Clinical Trials/NCT03819101
Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer
Is NCT03819101 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments including Acetylsalicylic acid and Atorvastatin for prostate cancer.
Treatment: Acetylsalicylic acid · Atorvastatin — This is a 2x2 factorial randomized, multicenter, international, open phase III trial. The primary objective is to evaluate the benefit of acetylsalicylic acid and atorvastatin on overall survival (OS) (main endpoint) for patients with castrate-resistant prostate cancer starting first line treatment for CRPC
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: androgen deprivation therapy (orchiectomy, LHRH agonist, LHRH antagonist) — castrate-sensitive or castration-resistant
CRPC defined as tumor progression ... while on Androgen Deprivation Therapy (orchiectomy, LHRH agonist or -antagonist)
Cannot have received: life-prolonging treatment for CRPC (abiraterone, enzalutamide, radium-223, docetaxel, cabazitaxel, sipuleucel-T)
Exception: The use of these agents together with Androgen Deprivation Therapy (ADT) for castrate-sensitive disease is allowed.
No previous use of life-prolonging treatments for CRPC (including abiraterone, enzalutamide, radium-223, docetaxel, cabazitaxel, and sipuleucel-T). The use of these agents together with Androgen Deprivation Therapy (ADT) for castrate-sensitive disease is allowed.
Lab requirements
Kidney function
calculated creatinine clearance ≥ 50 ml/min, according to the formula of cockcroft-gault
Liver function
ast and alt ≤ 3xuln and no signs for cholestasis
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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