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OncoMatch/Clinical Trials/NCT03769766

Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance

Is NCT03769766 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies Curcumin for prostate cancer.

Phase 3RecruitingUniversity of Texas Southwestern Medical CenterNCT03769766Data as of Jun 2026

Treatment: CurcuminThis is a prospective study to determine if the use of curcumin randomized against placebo will reduce cancer progression in patients with prostate cancer undergoing active surveillance.

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Extracted eligibility criteria

Treatments studied

Other

Curcumin

Cancer type

Prostate Cancer

Disease stage

Grade: ≤6 (gleason)

Demographics

Ages 40–89
Male only

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: radiotherapy

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: chemotherapy

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: hormonal therapy

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: oral glucocorticoids

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: GnRH analogue

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: surgery (prostatectomy)

Any previous prostate cancer treatment (radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, prostatectomy)

Cannot have received: 5α-reductase inhibitor

Exception: use within 6 months of screening

Concurrent or previous use within 6 months of screening of any 5α-reductase inhibitor

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • UT Southwestern Medical Center · Dallas, Texas

Showing up to 5 US sites.

See all sites on ClinicalTrials.gov →

Frequently asked questions

Is NCT03769766 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

Is there an age limit?

Yes. Patients must be 89 years or younger and at least 40 years old.

Is this trial open to female patients?

No. This trial enrolls male patients only.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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