OncoMatch/Clinical Trials/NCT03739502
A Randomized Phase II Study of Hyperbaric Oxygen in Improving Engraftment in Umbilical Cord Blood Stem Cell Transplant
Is NCT03739502 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Hyperbaric oxygen for aml.
Treatment: Hyperbaric oxygen — The UCB transplant is a type of stem cell transplant used to treat cancer of the blood or lymph glands. The UCB transplant has advantages over other types of transplants such as ease of obtaining the umbilical cord blood, absence of donor risks, reduced risks of contagious infections, and the availability for immediate use. The UCB transplant is also associated with a lower incidence of graft versus host disease, or GvHD (in GvHD, the transplanted graft attacks the recipient organs).
Check if I qualifyExtracted eligibility criteria
Cancer type
Acute Myeloid Leukemia
Non-Hodgkin Lymphoma
Hodgkin Lymphoma
Acute Lymphoblastic Leukemia
Myelodysplastic Syndrome
Biomarker criteria
Required: BCR BCR-ABL gene positivity
BCR-ABL gene positivity (high-risk ALL feature)
Required: ABL1 BCR-ABL gene positivity
BCR-ABL gene positivity (high-risk ALL feature)
Excluded: NPM1 mutation without FLT3-ITD
NPM1 mutation without FLT3-ITD (favorable risk, excluded from AML CR1 inclusion)
Excluded: FLT3 ITD
NPM1 mutation without FLT3-ITD (favorable risk, excluded from AML CR1 inclusion)
Excluded: CEBPA double-mutated
double-mutated CEBPA (favorable risk, excluded from AML CR1 inclusion)
Prior therapy
Must have received: high-dose therapy — relapsed
relapsed following high-dose therapy (HD) [Hodgkin's disease]; relapsed post-high-dose therapy and autologous transplantation [NHL]
Cannot have received: intrathecal chemotherapy
Exception: within 2 weeks of starting preparative regimen
Patients who had intrathecal chemotherapy within 2 weeks of starting preparative regimen
Cannot have received: cranial irradiation
Exception: within 4 weeks of starting preparative regimen
cranial irradiation within 4 weeks of starting preparative regimen
Lab requirements
Kidney function
creatinine: ≤ 1.5 x uln
Liver function
alt, ast: < 4x iuln; total bilirubin: ≤ 2.0 mg/dl
Cardiac function
ef measured by 2d-echo or muga scan of ≥ 45%; ekg with no clinically significant arrhythmia
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Rochester · Rochester, New York
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