OncoMatch/Clinical Trials/NCT03714490
MRI Simulation-guided Boost in Short-course Preoperative Radiotherapy for Unresectable Rectal Cancer
Is NCT03714490 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies CAPOX for rectal neoplasms.
Treatment: CAPOX — Improvements in downstaging are required when using preoperative chemoradiation for unresectable rectal cancer. There is therefore a need to explore more effective schedules. The study arm will receive MRI simulation-guided boost in short-course preoperative radiotherapy followed by consolidation chemotherapy , which may enhance the shrinkage of tumor comparing with the concurrent chemoradiation.
Check if I qualifyExtracted eligibility criteria
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
No excision of tumor, chemotherapy or other anti-tumor treatment after the diagnosis
Cannot have received: other anti-tumor treatment
No excision of tumor, chemotherapy or other anti-tumor treatment after the diagnosis
Cannot have received: surgery
No excision of tumor, chemotherapy or other anti-tumor treatment after the diagnosis
Lab requirements
Blood counts
White blood cell count ≥3.5 x 10^9/L; Haemoglobin ≥100g/L; Platelet count ≥100 x 10^9/L
Kidney function
Creatinine ≤1.0× UNL; Urea nitrogen ≤1.0× UNL
Liver function
ALT ≤1.5× UNL; AST ≤1.5× UNL; ALP ≤1.5× UNL; TBIL ≤1.5× UNL
Adequate blood counts: White blood cell count ≥3.5 x 10^9/L Haemoglobin levels ≥100g/L Platelet count ≥100 x 10^9/L Creatinine levels ≤1.0× upper normal limit（UNL） Urea nitrogen levels ≤1.0× upper normal limit（UNL） Alanine aminotransferase(ALT) ≤1.5× upper normal limit（UNL） Aspartate aminotransferase(AST) ≤1.5× upper normal limit（UNL） Alkaline phosphatase(ALP) ≤1.5× upper normal limit（UNL） Total bilirubin(TBIL) ≤1.5× upper normal limit（UNL）
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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