OncoMatch/Clinical Trials/NCT03579875
Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
Is NCT03579875 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments for fanconi anemia.
Treatment: Total Body Irradiation (TBI) (Plan 1) · Cyclophosphamide (CY) (Plan 1) · Fludarabine (FLU) · Methylprednisolone (MP) · Donor mobilized PBSC infusion · G-CSF · Cyclophosphamide (CY) (Plan 2) · Rituximab · Busulfan · Alemtuzumab · Melphalan · Rituximab — This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine graft-versus-host disease (GVHD) immune suppression leading to earlier immune recovery and potentially a reduction in the risk of severe infections after transplantation.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Chemotherapy
Other
Cancer type
Myelodysplastic Syndrome
Demographics
Lab requirements
Blood counts
hemoglobin, WBC, platelet within 10% of upper and lower limit of normal range of test (gender based for hemoglobin)
Kidney function
serum creatinine < 1.8 mg/dl
Liver function
Adequate liver function (ALT < 2 x upper limit of normal)
Cardiac function
Adequate cardiac function
Adequate pulmonary, cardiac and liver function; Hematologic: hemoglobin, WBC, platelet within 10% of upper and lower limit of normal range of test (gender based for hemoglobin); Hepatic: ALT < 2 x upper limit of normal; Renal: serum creatinine < 1.8 mg/dl
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Masonic Cancer Center at University of Minnesota · Minneapolis, Minnesota
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT03579875 currently recruiting?
Yes, this trial is currently recruiting patients.
Is there an age limit?
Yes. Patients must be 65 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages