OncoMatch/Clinical Trials/NCT03498326
Gemcitabine and Celecoxib Combination Therapy in Treating Patients With R0 Resection Pancreatic Cancer
Is NCT03498326 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Gemcitabine and Gemcitabine for pancreatic cancer.
Treatment: Gemcitabine · Gemcitabine — The prognosis of pancreatic cancer is extremely poor, even in those patients who had underwent surgery, the 5-year survival is still less than 10%. Current guidelines recommend Gemcitabine monotherapy for R0 resection of pancreatic cancer. Inflammation plays an critical role in the development and progression of pancreatic cancer. Here we intend to assess the synergistic effect of using celecoxib in combination with gemcitabine on the treatment of R0 resection of pancreatic cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Pancreatic Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: surgery — R0 resection
Surgery for R0 resection
Cannot have received: gemcitabine chemotherapy (gemcitabine)
The gemcitabine chemotherapy regimen was not previously used for the treatment of other malignancies
Cannot have received: radiation therapy
Pancreatic cancer received radiotherapy before surgery
Lab requirements
Blood counts
neutrophil count is at least 1.5*10^9/ml, platelet count is at least 100*10^9/ml, hemoglobin is at least 80g/L
Kidney function
creatinine ≤ 1.2 mg/dL
Liver function
bilirubin does not exceed 1.5 times the upper limit of normal; alanine aminotransferase and aspartate aminotransferase does not exceed the upper limit of normal 3 times
Blood routine: The neutrophil count is at least 1.5*10^9/ml, and the platelet count is at least 100*10^9/ml.Hemoglobin is at least 80g/L. Liver function: bilirubin does not exceed 1.5 times the upper limit of normal; alanine aminotransferase and aspartate aminotransferase does not exceed the upper limit of normal 3 times; kidney function: creatinine ≤ 1.2 mg/dL.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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