OncoMatch/Clinical Trials/NCT03127774
Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma
Is NCT03127774 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Cisplatin and Sodium thiosulfate for adrenocortical carcinoma.
Treatment: Cisplatin · Sodium thiosulfate — Objectives: \- To determine intraperitoneal (IP) progression free survival after optimal debulking and heated intraperitoneal chemotherapy (HIPEC) with cisplatin in patients with IP spread of adrenocortical cancer. \- Determine morbidity of this procedure in this patient population. \- Determine the impact of surgery and HIPEC on quality of life (QOL) and hormone excess. \- Examine patterns of recurrence (local versus systemic). \- Determine overall survival after optimal debulking and HIPEC in patients with IP spread of adrenocortical cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Ovarian Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
ANC >1500/mm^3 without Filgrastim; platelets >75,000/mm^3; hemoglobin >8.0 g/dl
Kidney function
Serum creatinine ≤1.5 mg/dl unless creatinine clearance >60 mL/min/1.73 m2
Liver function
AST and ALT ≤5x ULN; total bilirubin <3x ULN; Childs B or C cirrhosis excluded; no severe portal hypertension
Cardiac function
No history of congestive heart failure or LVEF <40%; PT within 2 seconds of ULN (INR ≤1.8)
Hematology: ANC >1500/mm^3 without Filgrastim, platelets >75,000/mm^3, hemoglobin >8.0 g/dl. Chemistry: serum creatinine ≤1.5 mg/dl unless creatinine clearance >60 mL/min/1.73 m2, AST/ALT ≤5x ULN, total bilirubin <3x ULN, PT within 2 seconds of ULN (INR ≤1.8). Cardiac: no history of CHF or LVEF <40%.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Columbia University Medical Center · New York, New York
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