OncoMatch/Clinical Trials/NCT03099356
Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer
Is NCT03099356 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Cyclophosphamide and Sirolimus for metastatic thyroid cancer.
Treatment: Cyclophosphamide · Sirolimus — This study will be a non-randomized pilot trial using Cyclophosphamide and Sirolimus for the treatment of metastatic differentiated thyroid cancer. Patients will be treated with Sirolimus 4 mg, PO, days 1-28 as well as Cyclophosphamide 100 mg, PO, days 1-5 and 15-19. Cycle length will be 28 days. Patients will be monitored closely for toxicity and undergo imaging to evaluate efficacy once every 2 cycles.
Check if I qualifyExtracted eligibility criteria
Cancer type
Thyroid Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: radioiodine (Iodine-131)
Previous failure of Iodine-131 (131I) therapy or not candidates to receive 131I as assessed by treating physician.
Cannot have received: radioiodine (Iodine-131)
Exception: 4 weeks if negative post-treatment scan
131I therapy not allowed within 24 weeks before entry (4 weeks if negative post-treatment scan)
Cannot have received: chemotherapy
Chemotherapy...within 4 weeks
Cannot have received: tyrosine kinase inhibitor
tyrosine kinase inhibitor...within 4 weeks
Cannot have received: radiation therapy
radiation therapy within 4 weeks
Cannot have received: experimental therapy
Prior experimental therapy within 4 weeks of planned start of this trial
Cannot have received: mTOR inhibitor
Previous treatment with an mTOR inhibitor
Lab requirements
Blood counts
Adequate organ and marrow function
Kidney function
Adequate organ and marrow function
Liver function
Adequate organ and marrow function
Adequate organ and marrow function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Michigan Cancer Center · Ann Arbor, Michigan
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