OncoMatch/Clinical Trials/NCT03093688
Clinical Safty and Efficacy Study of Infusion of iNKT Cells and CD8+T Cells in Patients With Advanced Solid Tumor
Is NCT03093688 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies Infusion of iNKT cells and CD8+T cells for non-small cell lung cancer.
Treatment: Infusion of iNKT cells and CD8+T cells — Invariant Natural killer T (iNKT) cells are a unique subset of lymphocytes that express homogeneous TCR recognizing KRN7000 which was up-regulated by many kinds of cancer cells. PD-1+CD8+T cells of patients with advanced tumor are most likely tumor-specified. Our hypothesis is that immunotherapy strategy of infusion of iNKT cells and PD-1+CD8+T cells may decrease the tumor burden and improve overall survival. The purpose of this study is to assess the safety and efficacy of treatment of patients with advanced solid tumor by infusing of iNKT cells and PD-1+CD8+T cells.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Gastric Cancer
Renal Cell Carcinoma
Lab requirements
Blood counts
Hemoglobin ≥8.0 g/dL, Neutrophils count ≥1E9/L, Lymphocytes count ≥ lower limit of institutional normal, Platelet count ≥50E9/L
Kidney function
Serum creatinine ≤2.0 mg/dL
Liver function
Serum bilirubin ≤2 x upper limit of institutional normal, AST/ALT ≤2 x upper limit of institutional normal
Laboratory values within the following ranges prior to receiving treatment of study agent: Hemoglobin≧8.0 g/dL, Neutrophils count≧1E9/L, Lymphocytes count≧lower limit of institutional normal, Platelet count≧50E9/L, Serum creatinine≦2.0 mg/dL, Serum bilirubin≦2 x upper limit of institutional normal, AST/ALT≦2 x upper limit of institutional normal
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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