OncoMatch/Clinical Trials/NCT03050190
A Phase I/II Multiple Center Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Malignancies
Is NCT03050190 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies non-drug interventions for b-cell malignancies.
The study will evaluate safety and efficacy of a 4th generation chimeric antigen receptor gene-modified T cells targeting CD19 (4SCAR19) for patients with B cell malignancies. Clinical response and development of a standardized lentiviral vector and cell production protocol will be investigated. This is a phase I/II trial enrolling patients from multiple clinical centers.
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: CD19 surface expression
malignant B cell surface expression CD19 molecules
Prior therapy
Cannot have received: CAR-T cell therapy
Exception: if previously used CAR-T but was invalid
confirmed before used CAR - but invalid
Lab requirements
Blood counts
hgb > 80 g/l
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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