OncoMatch/Clinical Trials/NCT02290145
Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage
Is NCT02290145 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies TPF group for mouth neoplasms.
Treatment: TPF group — The purpose of this study is to To confirm the predictive value of CCND1 for TPF induction in cN2 patients with OSCC
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Biomarker criteria
Required: CCND1 high expression (high)
Disease stage
Required: Stage III, IVA
Performance status
KARNOFSKY 61–100
Karnofsky performance status (KPS) >60
Demographics
Prior therapy
Cannot have received: surgery
Exception: diagnostic biopsy
Surgical procedure of the primary tumors or lymph nodes (except diagnostic biopsy)
Cannot have received: radiation therapy
Previous radiotherapy
Cannot have received: cytotoxic chemotherapy
Previous chemotherapy
Lab requirements
Blood counts
white blood cell >3,000/mm3, hemoglobin >8g/L, platelet count >80,000/mm3
Kidney function
serum creatinine <1.5x ULN; creatinine clearance <30ml/min [excluded]
Liver function
ALAT/ASAT <2.5x ULN, bilirubin <1.5x ULN
Adequate hematologic function: white blood cell >3,000/mm3, hemoglobin>8g/L, platelet count>80,000/mm3. Hepatic function: ALAT/ASAT <2.5x ULN, bilirubin <1.5x ULN. Renal function: serum creatinine <1.5x ULN. Creatinine clearance <30ml/min [excluded].
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT02290145 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Does this trial require CCND1?
Yes, CCND1 high expression is a required biomarker for enrollment.
What disease stage is eligible?
Stage III or IVA is required.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify