OncoMatch/Clinical Trials/NCT01913106
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
Is NCT01913106 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies HSV-tk +Valacyclovir in Combination with Brachytherapy for prostatic neoplasms.
Treatment: HSV-tk +Valacyclovir in Combination with Brachytherapy — The purpose of this study is to conduct a Phase I - II clinical trial to extend preclinical studies involving in situ HSV-tk + Valacyclovir gene therapy in combination with brachytherapy for recurrent prostate cancer. This will provide a novel therapeutic approach to prostate cancer and hopefully impact on the development of metastatic disease and the control of preexisting metastasis.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Performance status
ZUBROD 0–1
Prior therapy
Must have received: hormonal therapy — after completion of definitive radiation therapy
after the hormone therapy at least 2 year after the completion of definitive radiation therapy
Must have received: definitive radiation therapy
completion of definitive radiation therapy
Cannot have received: experimental therapeutic cancer treatment
Not on any other experimental therapeutic cancer treatment
Lab requirements
Blood counts
WBC ≥ 4,000/μl, platelets ≥ 100,000/μl, hemoglobin ≥ 8.5 mg/dl, normal partial thromboplastin time and prothrombin time
Kidney function
Serum creatinine ≤ 1.6 mg/dl
Liver function
bilirubin < 1.5 mg/dl, AST and alanine aminotransferase < 2.5 times the upper limit of normal
WBC ≥ 4,000/μl, platelets ≥ 100,000/μl, hemoglobin ≥ 8.5 mg/dl, normal partial thromboplastin time and prothrombin time, bilirubin < 1.5 mg/dl, AST and alanine aminotransferase < 2.5 times the upper limit of normal, Serum creatinine ≤ 1.6 mg/dl
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Houston Methodist · Houston, Texas
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