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OncoMatch/Clinical Trials/NCT01887340

Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma

Is NCT01887340 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Carboplatin and Etoposide for seminoma.

Phase 2RecruitingGustave Roussy, Cancer Campus, Grand ParisNCT01887340Data as of May 2026

Treatment: Carboplatin · Etoposide · Cisplatin — The purpose of the study is to evaluate the ration of patients getting an lighten therapeutic strategy after 18F-fluoro-désoxyglucose positron emission tomography (PET-TDM) in grade I (cohort 1) or metastatic (cohort 2) seminoma

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Extracted eligibility criteria

Cancer type

Testicular Germ Cell Tumor

Disease stage

Required: Stage I, IIB, IIC, III OF GOOD PROGNOSIS

grade I; grade IIB (retroperitoneal adenopathy diameter between 2 cm and 5 cm, regardless of the LDH); grade IIC (retroperitoneal adenopathy diameter higher than 5 cm, regardless of the LDH); grade III of good prognosis (supradiaphragmatic reach with ganglionic metastasis and LDH < 2 times normal limit and/or supradiaphragmatic reach with pulmonary metastasis and LDH < 2 times normal limit) either at initial diagnosis or relapse of a grade I seminoma)

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: radiotherapy

No prior treatment with radiotherapy

Cannot have received: chemotherapy

No prior treatment with chemotherapy

Lab requirements

Blood counts

PNN >= 1500, platelets >= 100 000

Kidney function

Serum creatinine <140 µmol / L (or clearance> 60 mL / min)

Liver function

ASAT (SGOT) and ALAT (SGPT) <= 1.5 x the upper limit nromale; bilirubin <= the upper limit nromale

PNN >= 1500, platelets >= 100 000, bilirubin <= the upper limit nromale; ASAT (SGOT) and ALAT (SGPT) <= 1,5 x the upper limit nromale; Serum creatinine <140 µmol / L (or clearance> 60 mL / min)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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